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KMID : 0616120110420030271
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Korean Journal of Pharmacognosy
2011 Volume.42 No. 3 p.271 ~ p.275
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Enhancement of Bioactivity of Sosihotang with Steaming Process
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Weon Jin-Bae
Ma Jin-Yeul
Yang Hye-Jin
Lee Bo-Hyoung
Yun Bo-Ra
Ma Choong-Je
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Abstract
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Sosihotang is a herbal medicine traditionally used to treat chronic liver disease. This study was performed to investigate the effect of steaming Sosihotang at a on its major compounds and neuroprotective activity. We evaluated quantitative changes of 6 major compounds in Soshihotang, saikosaponin A, homogentisic acid, baicalin, ginsenoside , glycyrrhizin and 6-gingerol using HPLC-DAD. After steaming produce, saikosaponin A, homogentisic acid, baicalin, glycyrrhizin and 6-gingerol in Sosihotang were decreased and ginsenoside was increased. The neuroprotective activity of steamed Sosihotang was determined by MTT assay, comparing to Sosihotang. The steamed sosihotang showed a higher neuroprotective activity than Sosihotang. In conclusion, steam produce could improve neuroprotective activity of Soshihotang
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KEYWORD
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Soshihotang, Steamed produce, Major compounds, Neuroprotective activity
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